Teams that finished first in the regular season, plus one team winning the playoff round from each division were promoted to Lega Pro Prima Divisione; teams that finished last in the regular season, plus two relegation playoff losers from each division were relegated to Serie D. In all, six teams were promoted to Prima Divisione, and nine teams were relegated to Serie D. On July 9, the Covisoc (Commissione di Vigilanza sulle Società Calcistiche, Vigilancy Commission on Football Clubs) organization announced that 11 Seconda Divisione clubs did not pass the financial requirements in order to be admitted to the league.
On July 30, Potenza was called up to Prima Divisione to fill a vacancy.
It was to feature nine teams promoted from 2008–09 Serie D as division winners: Biellese (that did not file any registration papers, and thus, was excluded from the league and replaced by Spezia) - Girone A, P.B.
The eight vacancies were successively filled as follows: Spezia promoted to Lega Pro Prima Divisione.
hc - higher classified team wins Cisco Roma promoted to Lega Pro Prima Divisione.