The 2009–10 Liga Femenina de Baloncesto was the 47th edition of the Spanish premier championship for women's basketball teams.
Defending champion Ros Casares again defeated CB Avenida in the final to win its fourth title in a row, an overall seventh.
1 Despite qualifying for the FIBA EuroCup Uni Girona withdrew from the competition for financial reasons.
2 Despite avoiding relegation Real Canoe withdrew from the championship for financial reasons.
CB Puig d'en Valls subsequently bought its place in the championship.