The 2009–10 Malian Première Division is the 45th season and current championship of the Highest-Level of Professional Soccer in Mali.
[1] Though the competition's structure has varied over time, the size of the league remained the same from the previous season.
The league will be conducted over 26 rounds as well with all teams playing against each other twice on a home and away basis.
The defending champions are Djoliba AC who won their second consecutive and 21st overall league championship.
One club comes from Malian Groupe B league soccer tournament (for teams near Bamako and the west) and the other is the Malian Groupe A league which is a tournament for clubs outside Bamako.