The 2009–10 Morehead State Eagles men's basketball team represented Morehead State University in the 2009–10 NCAA Division I men's basketball season.

The Eagles were led by head coach Donnie Tyndall in his fourth year leading the team.

Morehead State played their home games at Ellis Johnson Arena in Morehead, Kentucky, as members of the Ohio Valley Conference.

The Eagles finished conference play with an 15–3 record, earning the second seed in the Ohio Valley tournament.

The Eagles won their first game in the CBI, but were eliminated in the quarterfinals by Boston University, 91–89, in overtime.