The season formally opened on October 11, 2009, and ended on August 18, 2010.

The league started the season with the Philippine Cup, or the traditional All-Filipino Conference, while finishing the season with the import-laiden Fiesta Conference.

The Puerto Princesa City Government hosted the 2010 PBA All-Star Weekend at the Puerto Princesa Coliseum in Palawan on April 25, 2010.

Key transactions: Trades: Signing: Resigning: The PBA board approved the rule changes for implementation starting in the pre-season games:[7][8] The season began on October 11 with the Purefoods Tender Juicy Giants defeating the Burger King Whoppers, 90–83.

The muses for the participating teams are as follows: Key transactions: Trades: The 2010 PBA All-Star Weekend was held from April 22 to 25 at the Puerto Princesa Coliseum, Puerto Princesa, Palawan.