[4] Espanyol's 2009-10 La Liga campaign got underway on 30 August with a 1–0 away loss to Athletic Bilbao at San Mamés, and their first home game on 12 September also ended in defeat, with Real Madrid winning 3–0 at Cornellà-El Prat.

[5] Their first win, and first goals, of the season came a week later at Estadio Riazor, with José Callejón, Juan Forlín and Joan Verdú all on target in a 3–2 victory over Deportivo La Coruña.

[9] Their Copa del Rey campaign began at the end of October, with the first leg of their round of 32 tie against fellow top fight side Getafe, who took a 2–0 victory at Coliseum Alfonso Pérez.

Sporting de Gijón won 1–0 at El Molinón, and then consecutive home matches against Getafe saw Espanyol eliminated from the Copa del Rey after a 1–1 draw before losing 2–0 in the league.

At home, however, they secured victories over Real Zaragoza, Athletic Bilbao, Deportivo La Coruña, Sevilla and Atlético Madrid, and drew with Mallorca, Villarreal, Sporting de Gijón and Barcelona.

On 25 April, Espanyol secured their first away victory in over eight months[5] as a García free kick gave them a 1–0 win over Almería at Estadio de los Juegos Mediterráneos.