The 2009–10 season was the 103rd in the history of Real Betis and their first season back in the second division since 2001.

The club participated in Segunda División and the Copa del Rey.

[1][2] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Win Draw Loss Fixtures Source: Competitions Source: BDFutbol