Sampdoria also participated in 2009–10 Coppa Italia, starting from the 3rd round.

On 16 May 2010, Sampdoria finished their great season with a 1–0 win against S.S.C.

Napoli, securing 4th place in 2009–10 Serie A and the final 2010–11 UEFA Champions League qualification spot.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.