The Musketeers competed in the Atlantic 10 Conference and played their home games at the Cintas Center.

The Musketeers lost in the semifinals of the 2010 Atlantic 10 men's basketball tournament to Richmond.

Xavier received an at-large bid to the NCAA tournament, as a #6 seed.

In the Sweet Sixteen, they fell to Kansas State in double overtime.

Xavier received a #4 seed in the NCAA tournament where they advanced to the Sweet Sixteen before losing to Pittsburgh.