Mobile quarterback Anthony Haney (New Jersey recruit) was injured in an early preseason practice due to a career ending arm injury Mark Herzlich, a senior linebacker and the 2008 ACC Defensive Player of the Year, revealed on May 14 that he had been diagnosed with Ewing's sarcoma, a cancer most commonly found in bone or soft tissue.

[2] In the Eagles 52–20 win over NC State, Sophomore RB Montel Harris set two single-game school records when he rushed for 264 yards and 5 TDs.

During the broadcast, star LB Mark Herzlich, who was forced to miss the entire 2009 season after being diagnosed with Ewing's Sarcoma, publicly announced that he was cancer-free.

Amazingly, Isaac Johnson stripped Riley Skinner and Wes Davis recovered the ensuing fumble to snatch victory from the jaws of defeat.

True freshman Luke Kuechly was pressed into service as a weakside linebacker due to the unexpected departure of Herzlich and became a national sensation.