[2] Local favourite Felipe Massa won the 2008 Brazilian Grand Prix for Ferrari as Lewis Hamilton picked up the World Championship for McLaren by overtaking Timo Glock on the last corner of the race for 5th.
The race has a history of home success, with Massa, Ayrton Senna, Nelson Piquet Sr, Carlos Pace and Emerson Fittipaldi winning.
Q2 also saw the elimination of championship leader Jenson Button down in fourteenth and behind Jaime Alguersuari, Kamui Kobayashi and Romain Grosjean, the three least-experienced drivers in the field.
Pole-sitter Barrichello controlled the first phase of the race, though Mark Webber and Robert Kubica stayed in touch, just two and a half seconds adrift.
He proceeded to take Grosjean around the outside at Turn 6 and then Nakajima at the first corner once green-flag conditions resumed, before being held up by debutant Kamui Kobayashi.
Barrichello was unable to sustain the pace needed to maintain his lead over Webber, and in the first round of pit stops, the home town driver was passed by the Australian before coming under fire from Robert Kubica.
Meanwhile, Lewis Hamilton — having started seventeenth — had pitted on the first lap and removed the softer tyre compound as his team switched him to a one-stop strategy.
Other incidents early in the race saw Nick Heidfeld run out of fuel after his fuel-rig malfunctioned, whilst Kobayashi's blocking tactics removed fellow countryman Kazuki Nakajima's front wing, and the Williams driver crashed heavily at the fourth corner.
The second stage of the race saw Button leading a group of four one-stopping drivers, with their ultimate success or failures having consequences on the championship standings given Barrichello's position.
He resumed in eighth, with Vettel's fourth placing meaning that, barring a dramatic turn in events, Button would be the 2009 World Champion even if he retired.
Mark Webber, who had led unchallenged since the first stops, went on to win the race, with Robert Kubica securing BMW Sauber's first podium since Malaysia.
He also became the second driver in succession to win a World Championship by finishing fifth in Brazil whilst driving a Mercedes-powered car carrying the number 22.