The Home Opener was on April 10 with the Indians losing 13–7 to the Toronto Blue Jays.
The season ended on October 4 against the Boston Red Sox at Fenway Park.
Several players were sent to the disabled list including Travis Hafner, Grady Sizemore, and Asdrúbal Cabrera.
The poor play and injuries allowed many minor league players to come up from AAA Columbus and contribute to the Indians.
A turning point came in the season when on May 25, when the Indians defeated the Tampa Bay Rays 11-10 after coming back from a 10-0 deficit.