The regular season started on September 30, 2010, and ended on May 15, 2011.

Regal FC Barcelona won their 16th title.

Teams promoted from 2009–2010 LEB Teams relegated to 2010–2011 LEB Oro Last updated: 1 October 2010 Palacio de Vistalegre 1Coach Manuel Hussein was sacked after the day 6.

3Aíto Gª Reneses and Trifón Poch, sacked after the day 17.

Italics indicate holder of a Euroleague Basketball (company) "A License", giving the team automatic access to the 2011–12 Euroleague regardless of league position.