The 2010–11 Amlin Challenge Cup pool stage was the opening stage of the 15th season of the European Challenge Cup, the second-tier competition for European rugby union clubs.

It began on 7 October 2010 at Kingston Park in Newcastle with a match between Newcastle Falcons and Bourgoin, and was completed on 23 January 2011.

The pool winners advanced to the knockout stage, where they were joined by three entrants from the Heineken Cup pool stage.

These teams then competed in a single-elimination tournament that ended with the final on 20 May 2011 in Cardiff at Cardiff City Stadium.

All times are local to the game location.