Rosario Central and Gimnasia y Esgrima (LP) played in the relegation/promotion playoffs against All Boys and Atlético de Rafaela, respectively, to determine the other two teams for this season.
Following those matches, Gimnasia stayed in the Primera División, while Rosario Central was relegated and replaced by All Boys.
Source:[48] Source:[49] Since Huracán and Gimnasia (La Plata) finished with the same relegation co-efficient at the dividing line, a one-match playoff was held to determine who had to play in the relegation/promotion playoffs and who had to be directly relegated to the Primera B Nacional.
The 17th and 18th placed teams in the relegation table (River Plate and Gimnasia y Esgrima (LP), respectively) played the 3rd and 4th-place finishers of the 2010–11 Primera B Nacional season (San Martín (SJ) and Belgrano, respectively), the winner of each claiming a spot in the following Primera División season.
Qualification for the 2011 Copa Sudamericana was determined by an aggregate table of the Apertura 2010 and Clausura 2011 tournaments.