There were significant team changes from the 2009–10 Belize Premier Football League closing season.
Georgetown Ibayani, Paradise Freedom Fighters and Shanaiah Corozal left the league and in came Griga United, San Felipe Barcelona and Toledo Ambassadors.
Round 13:[11] Hankook Verdes were awarded a victory, due to the withdrawal of San Pedro Sea Dogs.
Round 10:[13] Toledo Ambassadors were awarded a victory, due to the withdrawal of San Pedro Sea Dogs.
Round 11:[14] Griga United were awarded a victory, due to the withdrawal of San Pedro Sea Dogs.
After Round 7 of the competition it was announced by BPFL Manager Marvin Ottley that the league decided to abort the remaining games of the regular season and go straight to the playoffs.