The Wildcats, led by head coach Clifford Reed, played their home games at Moore Gymnasium and the Ocean Center, both in Daytona Beach, Florida, as members of the Mid-Eastern Athletic Conference.

The Wildcats won the MEAC regular-season title, their first since joining Division I in 1980.

[1] The Wildcats were the number one seed in the MEAC tournament, but were upset in the semifinals by Morgan State.

[2] Bethune–Cookman failed to qualify for the NCAA tournament, but received an automatic bid to the 2011 NIT as the regular-season champions of the MEAC.

The Wildcats were eliminated in the first round of the NIT by Virginia Tech, 79–54.