The season officially opened on December 27, 2010, when Pittsburgh defeated Connecticut, 78–63, and ended on March 5, 2011, with a 72–56 victory for St. John's over South Florida.

Play began at noon on Tuesday, March 8 in Madison Square Garden, when 9th-seed Connecticut defeated 16th-seed DePaul, 97–71.

[4] Play ended on Saturday, March 12, when Connecticut won their fifth game in five days, defeating Louisville, 69–66, for their seventh Big East Championship.

[30] On January 6, the Wooden Award midseason watchlist was released, and included five Big East players.

In addition, five Big East players who were on the preseason list did not appear at midseason: Corey Fisher, Ashton Gibbs, Jeremy Hazell, Kris Joseph, and Brandon Triche.

[40] On February 11, the Naismith Top 30 was announced, and included newcomers Jackson, Wanamaker, and Notre Dame guard Ben Hansbrough.

The regular season team, individual, and attendance figures include all conference and non-conference games played from November 8, 2010 through March 5, 2011.

[102] Notre Dame senior guard Ben Hansbrough was named Player of the Year, and head coach Mike Brey was named Coach of the Year, after both leading the Fighting Irish to a surprising second-place finish in the conference regular season, with a record of 14–4.

[101] Defensive Player of the Year Rick Jackson, a senior guard from Syracuse, was chosen for his shot-blocking and rebounding dominance, having led the Big East in both of these statistics during both the conference and non-conference season.

Hardy's teammate Justin Burrell was also honored with the Sixth Man Award, for being key to the Red Storm's success, averaging 6.6 points on 51.1 percent shooting, 5.0 rebounds and 21.1 minutes off the bench.

Notably absent from the list was Preseason Rookie of the Year Fab Melo, a center from Syracuse, who only averaged 9.4 minutes and 2.2 points off the bench.

[111] For the second consecutive year, Notre Dame senior forward Tim Abromaitis was named to the men's basketball Academic All-America First Team, by CoSIDA and ESPN The Magazine.

[112] A graduate student, Abromaitis was pursuing an MBA, specializing in finance, and achieved a 3.72 GPA during his penultimate season with the Fighting Irish.