[3] On 18 August, Israeli international centre-back Dekel Keinan was finally able to complete a deal that was set up earlier in the close season, after receiving his work permit.

Following an opening-day 4–0 win over Wigan Athletic at the DW Stadium on 14 August,[5] a result that briefly put them top of the entire English football pyramid for the first time since the opening day of the 1957–58 season, Blackpool earned the League Managers Association's "Performance of the Week Award".

[9] Varney scored on his debut in the following day's fixture: a 2–2 draw with Fulham at Bloomfield Road, in what was the first-ever Premier League game played at the ground.

DJ Campbell, whose hat-trick in the second leg of the play-off semi-final against Nottingham Forest helped put Blackpool in the final, was signed on a permanent basis after his two loan spells during the 2009–10 campaign.

[12] On 1 September, the Seasiders also finalised deals with Australian midfielder David Carney[13] and Ghanaian goalkeeper Richard Kingson,[14] giving Ian Holloway thirty available players to work with until January.

A penalty from Charlie Adam just before half-time was the difference until DJ Campbell, with his first goal as a permanent Blackpool player, scored in injury time to seal the Tangerines' second Premier League victory in four games.

A Charlie Adam error inside the visitors' six-yard box allowed Nikola Žigić to double their lead just before the hour mark, and that is how the score remained.

Séamus Coleman, making his first appearance against Blackpool since he helped the club to promotion during his loan spell the previous season, stroked the ball under the body of Matthew Gilks.

In front of a crowd of 31,000 at Upton Park, the two teams held out for a goalless draw, a result that dropped Blackpool a place in the table to fifteenth.

Luke Varney doubled the visitors' lead twelve minutes into the second half with his fifth League goal of the season, which made him the club's joint-top scorer with Marlon Harewood.

The forward, who was once signed to Birmingham by Sunderland manager Steve Bruce, doubled the visitors' lead in injury time with his fifth goal of the season, joining Marlon Harewood and Luke Varney at the top of the club's scoring chart.

Less than a minute later, Luke Varney brought down Carlos Tevez in the area to give away a penalty; however, the Argentine put the ball wide of Richard Kingson's right-hand post to keep the score 1–0.

[30] At the halfway stage of their Premier League season, Blackpool had played nineteen games, of which they had won seven, drawn four and lost eight, giving them 25 points.

[31] Premier League duty resumed on 12 January, with a midweek visit of Liverpool to Bloomfield Road, a rescheduled fixture after the previous month's postponement.

It completed Blackpool's first double over Liverpool since the 1946–47 campaign, shortly before the Reds won their fifth First Division championship, and it elevated them to ninth place in the table.

On 21 January, Dekel Keinan left Bloomfield Road for Cardiff City after finding his chances with the Seasiders limited due to the pairing of Ian Evatt and Craig Cathcart in central defence.

[38] On the same day, after suffering six defeats in seven games, Ian Holloway brought in Moroccan defender Salaheddine Sbaï on loan from Nîmes until the end of the season, with an option to extend the deal for another year in the summer.

He was joined by loan signings James Beattie from Rangers, Jason Puncheon from Southampton, and Sergei Kornilenko from Zenit Saint Petersburg.

Two minutes later, Charlie Adam put Blackpool ahead for the first time with a diving header after DJ Campbell's strike came back off the underside of the crossbar.

[42] Ten days later, Blackpool welcomed Tottenham Hotspur, conquerors of Milan the previous week, to the seaside for their fixture rescheduled from 19 December.

With Charlie Adam sitting out the first of two games due to suspension, having picked up ten disciplinary points, David Vaughan captained the Seasiders.

A first-half Charlie Adam double gave the visitors the half-time lead; however, strikes from Christopher Samba and, in injury time, Junior Hoilett, meant the honours were shared.

A Bobby Zamora double inside half an hour, plus a second-half strike by Dickson Etuhu, condemned Ian Holloway's men to their eighth defeat in eleven Premier League games.

The home side conceded a goal inside three minutes, scored by Hugo Rodallega, after a wayward free-kick and subsequent slip by Craig Cathcart.

A wreath in memory of former Blackpool player and manager Allan Brown, who died earlier in the week, was laid behind the South Stand goal.

[56] On 22 May, exactly 365 days since their Wembley promotion, Blackpool travelled to Old Trafford to face Manchester United, who were crowned champions a week earlier with their draw at Blackburn Rovers.

These were goalkeepers Paul Rachubka and Richard Kingson, defenders Danny Coid, Rob Edwards and David Carney, midfielders Malaury Martin, Ishmel Demontagnac and Jason Euell, and forward Marlon Harewood.

Meanwhile, twelve-month options were activated on seven players: defenders Neal Eardley and Ian Evatt, midfielders Charlie Adam, Keith Southern and Gary Taylor-Fletcher, and forwards Billy Clarke and Louis Almond.

These were goalkeepers Matt Gilks and Mark Halstead, defenders Stephen Crainey and Ashley Eastham, midfielder David Vaughan, and forward Brett Ormerod.

[58] Ormerod accepted a one-year contract,[59] but Vaughan turned down his offer, stating that he wanted to continue playing in the Premier League.