The 2010–11 British and Irish Cup was the 2nd season of the annual rugby union competition for second tier, semi-professional clubs from Britain and Ireland.

First round matches began on Friday 15 October 2010 and the final was held on Saturday 7 May 2011.

Defending champions Cornish Pirates were unable to make it out of the pool stages.

Bristol lifted the cup, narrowly defeating Bedford Blues 17–14 in the first all-English final.

Touch judges: Ian Heard Graham Marshall