Under the stewardship of Jimmy Quinn and Gary Brabin Cambridge made two successive play-off finals but lost both to Exeter and Torquay respectively.

The signings of former Histon players Danny Wright and Danny Naisbitt, along with that of Kettering defender James Jennings and York winger Simon Russell, were announced at a game to celebrate the achievements of Director of Football Jez George in raising money and awareness for the club's 'Walk for Change' in May 2010.

[10][11][12] The signing of veteran striker Daryl Clare on 1 July, arriving for a fee of £10,000 on a two-year contract, led Ling to claim that his squad was all-but complete.

[15] The away loss to Mansfield Town was particularly difficult to stomach, as the winning goal game from a hotly disputed penalty.

[17] The game was also notable for summer signing Daryl Clare's first goal for the club, and former Histon striker Danny Wright's first at home.

[14] The club's fortunes were not helped by a hip injury to winger Conal Platt, and serious ankle damage to midfielder Adam Miller.

[20] This led to something of a renaissance in form – the club went unbeaten in the month's remaining four games, and won the last three, including a 3–0 home win against Lewes in the FA Cup Fourth qualifying round.

[21] Daryl Clare, who had struggled to find his old form since joining the club with just 1 goal in 13 appearances, was ruled out for 6 weeks at the end of the month with a finger injury.

[22] United's injury woes continued at the start of November, with commanding centre-back Brian Saah rule out for 6 weeks after undergoing a hernia operation.

[23] This ruled Saah out of the televised FA Cup First round tie at home to Huddersfield Town, which ended goalless, earning the club a lucrative replay.

[24] In the replay at the Galpharm Stadium, although leading through a Rory McAuley goal, Huddersfield scored twice in added time to knock the U's out.

The club's association with national brewers Greene King continues, with their IPA brand entering the second of a three-year deal to be worn on the front of shirts.