At the 2010 NHL Entry Draft, the Avalanche chose Joey Hishon, a centre, with the 17th overall pick.
The Avalanche lost number one goaltender Craig Anderson on October 26 to a knee injury.
Anderson, who was to be the backup that night in a game against the Vancouver Canucks, was participating in pre-game drills when he injured his knee.
Note: GP = Games played; TOI = Time on ice (minutes); W = Wins; L = Losses; OT = Overtime losses; GA = Goals against; GAA= Goals against average; SA= Shots against; Sv% = Save percentage; SO= Shutouts; G= Goals; A= Assists; PIM= Penalties in minutes †Denotes player spent time with another team before joining Avalanche.
The Avalanche's American Hockey League affiliate is the Lake Erie Monsters, based in Cleveland, Ohio.