The 2010–11 Coppa Italia, also known as TIM Cup for sponsorship reasons, was the 64th edition of the domestic competition.

As in the previous year, 78 clubs took part in the tournament.

Internazionale were the cup holders and successfully retained the trophy.

Teams entered the competition at various stages, as follows: Internazionale won 2–1 on aggregate.

Palermo won 4–3 on aggregate.