It began on 10 November 2010 with the first round and concluded on 18 May 2011 with the final which was held at GSZ Stadium.
Omonia won their 13th Cypriot Cup trophy after beating Apollon 4–3 on penalties in the final.
Teams from the two lower divisions (Third and Fourth) competed in a separate cup competition.
If both teams had scored the same number of home and away goals, then extra time was following after the end of the second leg match.
If there weren't scored any goals during extra time, the qualifying team was determined by penalty shoot-out.