Eleven of them have also competed in the 2009–10 season while the remaining three teams were promoted from the Second Division.
The teams ranked first through fourth will play for the championship and to participate in the European competitions.
Nea Salamis Famagusta and APEP Pitsilia were relegated at the end of the first stage of the 2009–10 season after finishing in the bottom two places of the table.
They were joined by Aris Limassol, who finished at the bottom of the second-phase Group C. The relegated teams were replaced by 2009–10 Second Division champions Alki Larnaca, runners-up AEK Larnaca and third-placed team Olympiakos Nicosia.
Note: Flags indicate national team as has been defined under FIFA eligibility rules.