The 2010–11 Czech Women's First League was the 18th season of the Czech Republic's top-tier football league for women.
Sparta Praha won the championship.
Eighth place Pardubice played a two-legged play-off against Slovan Liberec.
Liberec had won the second league promotion play-off against Jihlava 6–0 on aggregate.
[2] Pardubice then won the relegation play-off 3–2 on aggregate and remained in the first division.