It is set to start on 6 August 2010 with the recently relegated HB Køge facing off against last season's eighth-place finisher FC Fyn.
On March 4, 2011 Vejle BK and Kolding FC's application for a cooperation forming Vejle Boldklub Kolding was accepted by the Danish FA.
The division-champion and runners-up are promoted to the 2011–12 Danish Superliga.
The teams in the 14th, 15th and 16th places are relegated to either 2nd Division East or West, based on their respective locations.
No matter what position Kolding FC finishes in, they will be relegated to the Denmark Series.