The 2010–11 season of Schalke 04 began on 16 August 2010 with a DFB Pokal match against Aalen, and ended on 21 May 2011, the final of the DFB-Pokal, played against MSV Duisburg.

[1] Last Updated: 21 May 2011 Win Draw Loss Note: Results are given with Schalke 04 score listed first.

^1 The match on 1 April against St. Pauli was suspended in the 87th minute after an assistant referee was hit by a beer cup thrown from the stands with the score at 2–0 for Schalke.

The DFB Sports Court awarded the match to Schalke maintaining the 2–0 scoreline as well as the goalscorers and disciplinary records.

Win Draw Loss Note: Results are given with FC Schalke 04 score listed first.