They also took part in the inaugural Czech Supercup and played in the UEFA Europa League for the first time in their history.

Later in July the club played its first ever fixture in the Europa League, drawing 1–1 with Turkish side Beşiktaş in the third qualifying round of the competition.

Their European run was to be short-lived as the Turkish club won 3–0 in the return leg, sending Plzeň out of the competition, 4–1 on aggregate.

Despite being the defending champions of the Czech Cup, the club could only reach the quarter final stage, where they suffered a 4–2 aggregate loss to fellow Gambrinus liga side Mladá Boleslav.

Plzeň entered the UEFA Europa League in the third qualifying round, due to having won the 2009–10 Czech Cup.