The 2010–11 French Guiana Division d'Honneur was the 38th season of the top tier of football in Guyana.
As winners of the 2009–10 French Guiana Championnat National, ASC Le Geldar earned a berth in the overseas bracket in the seventh round proper of the Coupe de France.
Le Geldar played amateur French side, FC Martigues and lost 2–0.
For the 2011 edition of the CFU Club Championship, French Guiana was allowed to send two representatives to the tournament, but declined to participate.
As no French Guiana clubs entered in the 2010 CFU Club Championship, no teams from the Championnat National played in the Champions League.