During the 2010–11 season, Genoa competed in the Serie A, the top division of Italian football, and the Coppa Italia.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

As of 15 May Genoa C.F.C finished the season in tenth place on the league table, with 14 wins, 15 losses and 9 draws.