The season started with an eleven-match unbeaten league run, but after three successive defeats in all three competitions during the October, Poklepović was sacked.

Youth team coach Goran Vučević was appointed as caretaker manager and eventually signed a two-and-a-half-year contract in December.

A four-match run without victory, which started with a defeat by rivals Dinamo Zagreb that diminished hope for a championship title, saw Vučević leaving the club on mutual consent.

The club reached the group stage of the UEFA Europa League, eliminating Dinamo Bucharest and Unirea Urziceni in progress.

After their contracts ended, Josip Skoko left to Australia to play for Melbourne Heart and Goran Rubil was signed by the Greek team Asteras Tripoli.

Slovenian team Domžale beat them 3–1, while Mirko Oremuš scored their only goal and Senijad Ibričić earned a direct red card.

The game was played at Poljud in front of an attendance of 15,000 to commemorate 30 years after their quarter final match in 1979–80 European Cup which Hajduk won 3–2 but failed to advance in the semifinals due to away goals rule.

[13] Hrvoje Vejić and Marijan Buljat agreed on reducing their contractual obligations, while Ivo Smoje and Ivan Rodić were released to Osijek and Rijeka, respectively.

[15] Goalkeeper Vjekoslav Tomić and midfielder Florin Cernat left to Turkish Karabükspor,[16] where they were soon joined by Anthony Šerić.

[21] Only a few days later another injury hit Hajduk; Marijan Buljat broke a leg during the training meaning he would be out of action for six months.

[22] First day of August brought the second league game which resulted in a 2–2 away draw against Osijek, with Ibričić scoring a late equalizer from a penalty kick.

[24] In the second leg of Europa League qualifications Hajduk defeated Dinamo Bucharest 3–0 with goals from Vukušić, Brkljača and Tomasov.

[25] With an aggregate score 4–3 Hajduk advanced to the Europa League play-off round where they will meet another Romanian representative, Unirea Urziceni.

[31] In the second leg of Europa League play-off, Ante Vukušić scored a late equalizing goal for a 1–1 away draw, and an aggregate 5–2 win against Unirea Urziceni.

The game was played at sold out Park Mladeži and ended with a 1–1 draw, with Vukušić scoring his sixth league goal.

[38] Senijad Ibričić scored a goal for Bosnia and Herzegovina in the 3–0 win against Luxembourg,[39] and got a yellow card in the 2–0 defeat against France.

At the start of the second half Subašić saved a penalty, but his error lead AEK again to advantage when Nikos Liberopoulos scored.

Zenit led 3–0 with Jurica Buljat guilty for two penalties, but Marin Ljubičić and Ante Vukušić managed to score for a comforting 3–2 loss.

They missed some good opportunities in the first half which ended goalless, but AEK triumphed thanks to goals from Nacho Scocco, Kostas Manolas and substitute Ismael Blanco.

[62] Last league game of the year was a 3–1 away win against Šibenik, with goals from Tomasov, Ibričić and captain Srđan Andrić who recovered from injury.

[64] At the end of 2010 calendar year Hajduk was five points behind Dinamo Zagreb in domestic league and was eliminated from Cup and Europe.

[66] On 28 December, Goran Vučević signed a two-and-a-half-year contract and was officially appointed as Hajduk's manager after his role as caretaker.

[71] Hajduk sought a replacement for Strinić as they lacked left backs, and soon it was announced that Josip Barišić from Široki Brijeg signed a three-and-a-half-year contract.

[76] They drew 0–0 with Austria Wien on 29 January,[77] but three days later they beat Obolon Kyiv 3–2 with goals from brothers Sharbini and Vukušić.

[85] Anas Sharbini was suspended for the upcoming game against Zadar, after he drove his team-mates car on Poljud's athletics track.

Although Hajduk successfully overturned the early lead with Vejić and Brkljača scoring for 2–1 at half-time, Karlovac staged a second half come-back to win 3–2.

[93] Two days later, Ante Miše was appointed as Hajduk's manager for the second time, after a spell in 2008–09 season when he also replaced Vučević at the helm.

[103] Four days later, Balakov officially signed a two-year contract with a possibility of one-year extension if a championship title is won.

[104] That same day, it was officially confirmed that Hajduk will play a friendly match against Barcelona, scheduled on 23 July and this way continuing the celebration of the club's centennial.