Those cup defeats and a poor start to the league season led to manager John Hughes leaving by mutual consent in early October.

[2] Colin Calderwood was appointed as the new manager,[3] but struggled to make any sort of impression, as they were knocked out of the Scottish Cup by Ayr United[4] and fell into a relegation battle.

[6] The Edinburgh Evening News reported on 15 May that John Hughes was waiting to see which round Hibs will enter the UEFA Europa League at before finalising his preseason schedule.

[8] Hibs arranged domestic fixtures against Dunfermline Athletic and Queen of the South, a four-game tour of the Netherlands, and visits to Carlisle United and Blackpool either side of their European tie.

[9] A postponement of a league match against Celtic, due to their opponent's cup commitments, meant that Hibs were faced with a four-week gap between competitive fixtures.

[11] The Edinburgh Evening News reported on 13 May that Hibs had requested to begin the 2010–11 league season with an away fixture due to the redevelopment of Easter Road.

[1] Hibs lost their first home league game of the season, a controversial 3–0 defeat by defending champions Rangers in which both sides had a man sent off.

[17] Cup defeats by NK Maribor and Kilmarnock and that poor start to the league season led to Hughes leaving the club by mutual consent in early October.

[21] Further wins against St Mirren and Inverness put Hibs in contention for a top six finish,[22] but a defeat at Celtic Park ended such hopes.

[24] John Hughes chose to leave Anthony Stokes and Derek Riordan out of the starting lineup for the first leg in Maribor, playing Colin Nish as a lone striker instead.

[30] The match at Easter Road ended in a goalless draw, with goalkeeper Mark Brown to thank for producing a great save to keep the club in the cup.

[34] Hibs' first significant move in the close season was to release four first team players, goalkeeper Yves Ma-Kalambay, defender Darren McCormack, midfielder Patrick Cregg and forward Abdessalam Benjelloun.

[45] Poor results, including the Scottish Cup defeat by Ayr United, prompted chairman Rod Petrie to make a public statement in which he pledged to improve the playing squad.