The 2010–11 Horizon League men's basketball season marked the 31st season of Horizon League basketball.
In the preseason, Butler was the conference favorite – returning three starters from their NCAA runner-up team.
Butler received all first-place votes in the preseason poll of HL coaches, media, and sports information directors.
[1] The preseason player of the year was Shelvin Mack of Butler who was also named to the John R. Wooden Award preseason candidate list.
Matt Howard of Butler was named the tournament MVP for the second consecutive year and is the first Horizon League player to be named to the all-tournament team four times.