Linfield were crowned champions for the second successive season, after a 4–0 win over Lisburn Distillery on 26 April 2011.
[1] The same day, Newry City were relegated to IFA Championship 1 after a 4–0 loss to Glenavon.
[2] After a two-legged play-off against 2009–10 Championship 1 runners-up Donegal Celtic, Institute were relegated to the 2010–11 IFA Championship after an aggregate 1–0 loss, with Donegal Celtic taking their place for this season's IFA Premiership.
The promotion/relegation play-off was not played this season, because Championship 1 runners-up Limavady United were not eligible for promotion as they did not hold a domestic licence.
This meant that Newry City were automatically relegated, with Championship 1 winners Carrick Rangers replacing them in next season's Premiership.