The 2010–11 KNVB Cup was the 93rd edition of the Dutch national football annual knockout tournament for the KNVB Cup.
88 teams contested beginning on 18 August 2010 with the matches of Round 1 and ending with the final on 8 May 2011.
AFC Ajax would unsuccessfully defend on 8 May 2011 at De Kuip, Rotterdam, its 2010 title at the 2011 Cup losing to Twente, 3–2 (A.E.T.).
Twente qualified for the play-off round of the 2011–12 UEFA Europa League.
[3] Four amateur clubs competed in this stage of the competition for two places in the Second Round.