The Wildcats, coached by Matthew Mitchell, were a member of the Southeastern Conference, and played their home games on campus at Memorial Coliseum—unlike UK's famous men's program, which plays off-campus at Rupp Arena in downtown Lexington.

Victoria Dunlap, a 6'1 forward from Nashville, Tennessee, entered her senior season as one of the most decorated players in UK Hoops history.

She was named the 2010 Southeastern Conference Player of the Year by The Associated Press and the league's coaches, and was one of the 10 State Farm All-Americans named by the Women's Basketball Coaches Association the year before, becoming UK's first All-American since Valerie Still in 1983.

Dunlap was also picked to repeat as SEC Player of the Year by the league coaches, with eight of twelve votes.

The Lady Wildcats also had a large freshman class and Carly Marrow, a returning senior, was predicted to add experience to a young second string.