The 2010–11 LEN Euroleague was the highest-level competition in men's European club water polo.

It involved the champions and other top teams from European national leagues and ran from September 2010 to May 2011.

The LEN Euroleague 2010/11 has a slightly different format to previous years with the addition of a second group stage to replace the two-legged quarterfinals.

There are five phases to this competition: League positions of the previous season shown in parentheses.

th Title Holder Stadio Olimpico del Nuoto, Rome, Italy Semi-finals Third place Final