Politehnica Iași, Ceahlăul Piatra Neamț and Unirea Alba Iulia were relegated to Liga II after finishing the 2009–10 season in the bottom three places.
Ceahlăul Piatra Neamț and Unirea Alba Iulia made their immediate return to the second level, while Politehnica Iași ended a six-year tenure in the highest football league of Romania.
15th-placed team Pandurii Târgu Jiu, who originally were to be relegated as well, were allowed to remain in Liga I after Internațional Curtea de Argeș withdrew from the league because of financial reasons.
Victoria Brănești and Sportul Studențesc were promoted from Seria I while Târgu Mureș and Universitatea Cluj were promoted from Seria II, with Victoria Brănești and Universitatea Cluj being constrained to play their home games on grounds in other cities (than home based) as their did not meet Liga I requirements.
Defenders: Samoel Cojoc (7 / 0); Sergiu Costin (31 / 1); Milan Perendija (23 / 0); Laurențiu Petean (6 / 0); Cornel Râpă (33 / 1); Cristian Sârghi (16 / 2); Adrian Sălăgeanu (29 / 1).