The season began on January 15, 2010, and was scheduled to end in May 2011.
Ten teams were scheduled to compete throughout the entire season.
The Árabe Unido were crowned the champion after defeating San Francisco 1–0 in the first professional football match played in the newly-remodeled Estadio Rommel Fernández.
After clinching this win, the Árabe Unido earned the Panama 1 spot in the 2010–11 CONCACAF Champions League and Tauro the Panama 2 spot as the runner-up with the most points in the 2009 Apertura II and 2010 Clausura season.
[2] San Francisco obtained the Panama 3 spot after the Belize Premier Football League champion failed to meet the CONCACAF stadium requirements, thus the vacated spot was awarded to Panama's runner-up with less points.