JS Capoise and ASPDIF finished in 15th and 16th place in the overall table at the end of last season and were relegated to the Haitian second level leagues.
They were replaced by the two Haitian second level promotion playoff winners: Eclair and América des Cayes.
In addition, Aigle Noir and Racing FC finished in 13th and 14th place in the overall table at the end of last season and took part in promotion-relegation playoffs for their spots in the league against the runners-up of the second level promotion playoffs.
The 2010 Série de Ouverture began on 30 July 2010 and ended on 7 October 2010.
The 2010–11 Super Huit competition (English: Super Eight) is a knockout tournament played at the end of the season among the clubs finishing in the top 8 of the overall standings for the season for cash prizes.