2010–11 Macedonian First Football League

Renova were the defending champions having won their first Macedonian championship last season.

The competition was won by Shkëndija, who earned their first overall Macedonian title.

and Sloga Jugomagnat were expelled from the First League due to boycotting two matches in the season.

However, Napredok was directly promoted.2 Pobeda was expelled from the First League due to the eight-year suspension from FIFA for their involvement in match-fixing scandal.3 Vardar was initially relegated, but was stayed after was merged with Miravci, which won play-off match against Skopje.

During the first two rounds, each team played each other once home and away for a total of 22 matches.