The 2010–11 Memphis Grizzlies season was the 16th season of the franchise in the National Basketball Association (NBA), and the tenth for the franchise in Memphis.
The 2010–11 Memphis Grizzlies season marked their first playoff appearance since 2006.
This season also marked their first playoff win in a series in franchise history by defeating the first seeded San Antonio Spurs in six games in an upset, becoming the fourth eighth seed in league history to win a playoffs series against a number one seed, following the Denver Nuggets in 1994, the New York Knicks in 1999, and the Golden State Warriors in 2007.
However, the Grizzlies' season ended with a seven-game loss to the Oklahoma City Thunder in the Semifinals.