The 2010–11 Moldovan National Division (Romanian: Divizia Naţională) was the 20th season of top-tier football in Moldova.
Sheriff Tiraspol were the defending champions, having won their tenth Moldovan championship, all consecutively, the previous season.
During the first two rounds, each team plays each other once home and away for a total of 26 matches.
The pairings of the third round will then be set according to the standings after the first two rounds, giving every team a third game against each opponent for a total of 39 games per team.
Key numbers for pairing determination (number marks position after 26 games): Including matches played on 22 May 2011; Source: Soccerway Final classification.