Munster were drawn in Pool 3 of the Heineken Cup alongside the Ospreys, London Irish and RC Toulon.

Munster lost 23–17 away to London Irish, before defeating RC Toulon 45–18 at Thomond Park on 16 October 2010.

[2][3] Munster defeated Ospreys 22–16, but lost the reverse fixture at Liberty Stadium 19–15.

As a result of this defeat, Munster failed to qualify for the quarter-finals of the Heineken Cup for the first time in 13 years.

[12] [13] Note: Flags indicate national union under World Rugby eligibility rules.