The 2010–11 season in Primera División de Nicaragua will be divided into two tournaments (Apertura and Clausura) and will determine the 57th and 58th champions in the history of the league.

It will also provide the sole berth for the 2011–12 CONCACAF Champions League.

Promoted from Segunda División de Fútbol Nicaragua.

Relegated to Segunda División de Fútbol Nicaragua.

Relegation will be determined by the aggregate table of both Apertura and Clausura tournaments.