The 2010–11 Quaid-e-Azam Trophy was one of two first-class domestic cricket competitions that were held in Pakistan during the 2010–11 season.

It was the 53rd edition of the Quaid-e-Azam Trophy, contested by 22 teams representing regional cricket associations and departments,[a] and was followed in the schedule by the Pentangular Cup, contested by five teams representing the four provinces and the federal areas.

Each division was played in a round-robin of four-day matches starting on 23 October 2010, with five-day finals between the top two teams to determine the winners.

[3][4] Habib Bank Limited beat Pakistan International Airlines by 5 wickets in the Division One final to win the trophy.

[6] Four players were fined for a variety of offences during the final, including the use of abusive language and ball tampering.