Led by head coach Brad Greenberg, the team played in Big South Conference (BSC).

[2] Due to these violations, Radford suspended Greenberg for the final four games of the regular season as a self-imposed punishment.

[5] They earned a 13-5 record in conference play, which was good enough for the six-seed in the 2010 Big South men's basketball tournament.

After the season, the team lost Art Parakhouski, two-time Big South Player of the Year and the season's Division I leader in rebounds per game,[6] and second-team All-Big South player Joey Lynch-Flohr to graduation.

The NCAA was initially investigating the men's basketball program during the 2010-11 season for violations related to "impermissible benefits" for transportation and lodging for current and prospective players during the winter of 2009-10.