Al-Hilal won their fourth Crown Prince Cup title in a row and tenth in total after beating Al-Wehda 5–0 in the final.
First Division sides Al-Riyadh and Hajer qualified.
The Preliminary Round 2 matches were played on 29 & 30 September and 1 October 2010.
The final round matches were played on 9 and 27 November 2010.
The final was held on 15 April 2011 in the King Fahd International Stadium in Riyadh.