The 2010–11 Serie D was the sixty-third edition of the top level Italian non-professional football championship.
On April 10, 2011 Perugia became the first team to be promoted from Serie D in the season, winning the Girone E with three weeks remaining in the schedule, after a 3–2 home victory over Castel Rigone.
Teams placed second through fifth in each division enter a playoff tournament after the regular season where, eventually, three of the four semi-finalists of the final phase emerge.
The nine division winners enter a tournament to determine the over-all Serie D champion and is awarded the Scudetto Dilettanti.
The league admitted twenty teams from Eccellenza to fill vacancies created.
Promotion playoffs involved a total of 37 teams; four from each of the nine Serie D divisions (teams placed from 2nd through to 5th) with the Coppa Italia Serie D winner that is directly admitted to the Semi-final round.
In this season is qualified the finalist Turris, because the winner Perugia is already promoted in Lega Pro Seconda Divisione.